Sulochana Pradhan, MD Distinguished Professor in Breast Cancer
Investigator, Chan Zuckerberg Biohub
Associate Professor, Division of Hematology/Oncology
Department of Medicine
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Jennifer Rosenbluth, MD, PhD, is a medical oncologist who specializes in breast cancer, an Associate Professor in the Department of Medicine, an investigator in the Chan Zuckerberg Biohub, and a member of the Breast Oncology Program in the Helen Diller Family Comprehensive Cancer Center. The research in her laboratory utilizes three-dimensional organoid cultures of premalignant and tumorigenic breast tissues to identify heterogeneous populations of cells that promote cancer development and progression.
Publications
FNA biopsy of breast specimens effectively harvests cells for patient-derived organoids modeling ductal carcinoma in situ
Cancer Cytopathology
Organoid-evaluable clinical biomarkers predict drug responses and guide new breast cancer therapies.
bioRxiv : the preprint server for biology
Autophagy-targeted NBR1-p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH.
Nature cell biology
AXL promotes inflammatory breast cancer progression by regulating immunosuppressive macrophage polarization.
Breast cancer research : BCR
Implantation of engineered adipocytes suppresses tumor progression in cancer models.
Nature biotechnology
T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFα Inflammation.
Cancer immunology research
MAGIC matrices: freeform bioprinting materials to support complex and reproducible organoid morphogenesis.
bioRxiv : the preprint server for biology
Magnetic resonance imaging insights from active surveillance of women with ductal carcinoma in situ.
NPJ breast cancer
Implantation of engineered adipocytes that outcompete tumors for resources suppresses cancer progression.
bioRxiv : the preprint server for biology
Identifying Good Candidates for Active Surveillance of Ductal Carcinoma In Situ: Insights from a Large Neoadjuvant Endocrine Therapy Cohort.
Cancer research communications
A human breast atlas integrating single-cell proteomics and transcriptomics.
Developmental cell
Dermal Lymphatic Invasion, Survival, and Time to Recurrence or Progression in Inflammatory Breast Cancer.
American journal of clinical oncology
Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids.
Nature protocols
Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing.
Cell reports
Characteristics associated with inflammatory breast cancer (IBC): An epidemiologic study from a dedicated IBC program.
The breast journal
Discrepancy between FDG-PET/CT and contrast-enhanced CT in the staging of patients with inflammatory breast cancer: implications for treatment planning.
Breast cancer research and treatment
Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages.
Nature communications
A large peptidome dataset improves HLA class I epitope prediction across most of the human population.
Nature biotechnology
Inflammatory Breast Cancer: a Separate Entity.
Current oncology reports
Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.
Cell metabolism
Metabolic Characterization of Inflammatory Breast Cancer With Baseline FDG-PET/CT: Relationship With Pathologic Response After Neoadjuvant Chemotherapy, Receptor Status, and Tumor Grade.
Clinical breast cancer
A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene
Clinical cancer research : an official journal of the American Association for Cancer Research
Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America
ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy.
Molecular cancer
Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation.
Clinical cancer research : an official journal of the American Association for Cancer Research
Evaluation of p63 and p73 antibodies for cross-reactivity.
Cell cycle (Georgetown, Tex.)
The jury is in: p73 is a tumor suppressor after all.
Genes & development
A gene signature-based approach identifies mTOR as a regulator of p73.
Molecular and cellular biology